
High-efficiency keratinase | Feather-degrading enzyme | Disulfide bond hydrolase | Feed-grade keratinase – Feed additive | Leather unhairing enzyme | Cosmetic exfoliating enzyme | Medical-grade keratinase
Keratin degradation: Hydrolyzes insoluble keratin (feathers/hair) into soluble peptides/amino acids Breaks down feed-derived prolamins and antigenic proteins。
Declared activity: 5–200,000 U/g (solid powder)
Appearance: Off-white to pale yellowish-green powder
Source: Extracted from Bacillus licheniformis fermentation
Optimum Temperature: 50-60°C
Functionalities:
Breaks down feed-derived prolamins and antigenic proteins
Tenderizes meat by digesting indigestible protein structures
Degrades prion proteins (implicated in mad cow disease) by disrupting β-sheet structures
Keratinase is a broad-spectrum alkaline serine endopeptidase that efficiently degrades both soluble and insoluble proteins including collagen, bovine whey protein, and casein. Notably, it exhibits exceptional keratin degradation capability, converting insoluble keratin (feathers, hair, hooves) into soluble amino acids and peptides under mild conditions, offering significant advantages over conventional proteases.
Core Functions
Keratin degradation: Hydrolyzes insoluble keratin (feathers/hair) into soluble peptides/amino acids (e.g., serine, cysteine)
Extended functionalities:
Breaks down feed-derived prolamins and antigenic proteins
Tenderizes meat by digesting indigestible protein structures
Degrades prion proteins (implicated in mad cow disease) by disrupting β-sheet structures
Substrate Specificity
Primary substrate: Keratin (feathers, hair, horns)
Secondary substrates: Casein, collagen, etc.
Degradation efficiency ranking: Hemoglobin > fibrin > feather keratin > casein
Key Features
1)Catalytic Properties:
Hydrolyzes both peptide and non-terminal peptide bonds
Efficiently cleaves disulfide bonds (-S-S-) in keratin, disrupting its compact structure
2)Stability:
Thermostability AND pH tolerance
Enhances digestibility of complex proteins in animal feed.
Feed conversion rate booster enzyme improving nutrient utilization by 15-20%.
Feather waste treatment enzyme: Converts poultry feathers into amino acids and peptides within 48 hours (≥90% degradation rate).
Sustainable alternative to landfilling/incineration, reducing environmental pollution.
Exfoliating enzyme: Removes dead skin cells and excess keratin, improving skin permeability.
Key ingredient in keratinolytic skincare formulations.
Medical-grade keratinase:
Enhances drug penetration for psoriasis treatment.
Keratinase inhibitors reduce fungal invasiveness by 80%.
Leather unhairing enzyme: Replaces toxic sulfide-based processes.
Reduces COD emissions by 60%.
Gently dissociates elastic tissues while preserving leather quality.
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